Sildenafil (compound UK-92,480) has come to be known as the little blue pill that saved the world. It is commonly known as Viagra, which is one of its most popular brand names. This article focuses on the use of Sildenafil in impotence treatment. 

Impotence, also known as erectile dysfunction, is the inability to get and sustain a satisfactory erection to complete sexual intercourse. It is a very common condition in men, and its probability increases with age. It has a range of causes, both physical and psychological.

Physical causes include hormonal problems, injury, or narrowing of blood vessels going to the penis. Psychological causes include anxiety, depression, or even relationship problems. Treating impotence depends on what has caused it. 


It was synthesized by a group of pharmaceutical chemists working at a research facility in the UK. It was, at first, intended to be used in treating hypertension and angina pectoris. Clinical trials showed it to have little effect on angina but could instead induce penile erections. It was thereafter marketed for erectile dysfunction.

How Sildenafil UK Synthetic Drug works in Treating impotence

It acts by blocking PDE5, an enzyme found in various tissues, which promotes the breakdown of cGMP, which regulates blood flow in the penis. This, therefore, enables an increase in blood flow, enabling erection. The subject must, however, be sexually aroused for this to work.

It is usually taken orally for impotence treatment. Its onset is around 20 minutes and lasts for approximately two hours.

Side effects

The most common side effects include dizziness, headache, flushing, or stomach upset. You could also experience: 

  • Vision impairments, including blurred vision, increased sensitivity to light, or decreased vision.
  • Loss or decrease in hearing  
  • A painful or prolonged erection. This could result in the penis being damaged.

Do not hesitate to seek medical help if you experience the symptoms above or any others that you are uncertain of.

Food and alcohol interaction

Alcohol use can contribute further to lowering blood pressure which could already be lowered by Sildenafil. It is therefore advised to limit alcohol consumption while using the drug. It is also wise to decrease the amount of grapefruit in your diet while taking the drug. Grapefruit is known to increase the levels of Sildenafil in your body hence delaying the time it will take for the medication to work. 

Drug interaction

Drugs that interfere with the metabolism of Sildenafil include erythromycin, cimetidine, and protease inhibitors for the treatment of HIV infection. Care should be taken while under these medications.


Viagra is very effective in treating impotence. This has given more men the courage to come forward and be diagnosed with the condition. In countries such as the UK, however, it is available over the counter, which has made it prone to misuse. 

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